The Realtek/Windows combo works well to playback just about everything, you just cannot record decent audio with it. On boot, *if* the Scarlett is the default device, Win10 will take control of it, and may assign it (lock it) to some internal playback, which can effectively can 'lock it out' on you.
The issue is that for ASIO, only one program can control it, and if it is at a different sample rate than another program wants to use, then it will not play back. As mentioned above, setting Windows to use the Realtek as the default device, will make it leave the Scarlett alone. Some of the issues may lie in your Windows Sound Control Panel settings.
